The Report:
A detailed Breast Recurrence Score® report containing personalized, treatment-selection insights is generated for each patient.
The Score:
The Recurrence Score® result is based on a continuous scale of 0-100. The score reflects individual tumor biology—the higher the score, the higher the risk of distant recurrence and the higher the likelihood of chemotherapy benefit for that patient.
The Endpoints:
- Assesses the 9-year risk of distant recurrence in node-negative patients1
- Risk of 5-year distant recurrence or mortality in node-positive patients2
- Likelihood that chemotherapy will benefit your patient3,4
How your patient’s Recurrence Score result is generated
The Breast Recurrence Score test is a genomic test that measures the expression of cancer-related genes in your patient’s tumor. Your patient’s Recurrence Score result is based on the expression of 21 specific genes from tumor tissue removed during the surgery or core biopsy. Looking at the expression of this unique set of genes, the Recurrence Score result provides important information about how likely your patient’s cancer is to return and about your patient’s likelihood to benefit from chemotherapy
| BREAKDOWN OF THE 21 GENES INCLUDED IN THE ASSAY | ||||
| 16 Breast Cancer-Related Genes | ||||
| Estrogen | Proliferation | HER2 | Invasion | Others |
| ER | Ki-67 | GRB7 | Stromelysin 3 | CD68 |
| PR | STK15 | HER2 | Cathepsin L2 | GSTM1 |
| Bc12 | Survivin | BAG1 | ||
| SCUBE12 | Cyclin B1 | |||
| MYBL2 | ||||
| 5 Reference Genes | ||||
| Beta-actin | GAPDH | RPLPO | GUS | TFRC |
The relevance of the estrogen receptor (ER) score by reverse transcription polymerase chain reaction (RT-PCR)
A strong predictor of tamoxifen benefit in node-negative patients
While the Recurrence Score result and corresponding average rate of distant recurrence accounts for this effect of tamoxifen (in addition to the tumor’s fundamental prognosis), the single-gene ER score may also help clarify the magnitude of tamoxifen benefit.5
Getting the results
Most Breast Recurrence Score reports are available within 2 weeks from the date the specimen is received in the Exact Sciences lab. You can access the results through the online physician portal or receive the report by fax.
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References
